Systematically discover novel molecular glue degraders
Accelerate your path to first-in-class and best-in-class protein degraders with LCC — integrating AI, computational design, automated biology and chemistry to facilitate molecular glues discovery.
Our autonomous platform for novel MGD discovery systematically connects LCC capabilities to enhance speed and rationality
From intractable targets to novel hits
Move beyond known chemical space to confidently tackle MGD targets. Our AI-powered platform combines 40+ novel CRBN-binding cores with 150K building blocks to generate a diverse, synthetically accessible library of over 1.1 million virtual MGDs. They’re designed specifically for targets with no reported degraders yet and to identify novel hits for promising POIs.
From rational design to physical compounds
Close the loop between digital design and physical validation. Our integrated wet/dry lab capabilities use AI reaction models to prioritise the 450K most accessible compounds from the virtual library. An automated synthesis platform then delivers over 90% of these designs quickly, with a throughput of 600–1000+ compounds per week for rapid biological testing.
From fragments to accelerated leads
Transform promising starting points into validated candidates. This unified partnership covers the entire journey, leveraging end-to-end automated chemistry and biology validation. Our closed-loop platform provides the quality and volume of data needed to rapidly accelerate your project from initial fragments to an optimised lead.
The autonomous platform for novel MGD with enhanced speed and rationality
The platform built for partnership and novelty
Our MGD partnership offers a collaborative pathway to pioneer new therapies. Designed for partners pursuing first-in-class or best-in-class MGDs, the platform provides exclusive access to a proprietary chemical library and an end-to-end automated workflow to de-risk ambitious discovery. This flexible partnership model closely aligns with project success criteria.
discuss your next project
Our technology platform is built for your most challenging targets. If you’re ready for a data-driven, closed-loop approach to MGD discovery, schedule a call today.